Cross-Talk between Activated Human NK Cells and CD4+T Cells via OX40-OX40 Ligand Interactions

Cross-talk between activated human NK cells and CD4+ T cells via OX40-OX40 ligand interactions.

It is important to understand which molecules are relevant for linking innate and adaptive immune cells. In this study, we show that OX40 ligand is selectively induced on IL-2, IL-12, or IL-15-activated human NK cells following stimulation through NKG2D, the low affinity receptor for IgG (CD16) or killer cell Ig-like receptor 2DS2. CD16-activated NK cells costimulate TCR-induced proliferation, ...

OX40/OX40 Ligand Interactions in T-Cell Regulation and Asthma

The OX40 receptor is preferentially expressed by T cells, and its cognate ligand OX40L is primarily expressed by antigen-presenting cells such as dendritic cells following activation by thymic stromal lymphopoietin (TSLP). TSLP is released by the bronchial epithelium, airway smooth muscle, and some inflammatory cells in response to numerous insults such as allergens, viruses, and physical damag...

Tonsillar and Lung-Cultured Mast Cells Gene Expression Profiles between Human and OX40 on Human T Cells: Comparison of between OX40 Ligand on Human Mast Cells T Cell Proliferation by Direct Cross-Talk

Cross-Talk between Activated Human NK

CD28-independent costimulation of T cells by OX40 ligand and CD70 on activated B cells.

OX40 and its ligand (OX40L) have been implicated in T cell-dependent humoral immune responses. To further characterize the role of OX40/OX40L in T-B cell interaction, we newly generated an anti-mouse OX40L mAb (RM134L) that can inhibit the costimulatory activity of OX40L transfectants for anti-CD3-stimulated T cell proliferation. Flow cytometric analyses using RM134L and an anti-mouse OX40 mAb ...